FAMILIAL MACULAR DEGENERATION

Familial cerebro-macular degeneration and ataxia.

CASE 1 Colin D. (generation E in Fig. 1), born on 9 September 1958, of non-consanguinous parents, was admitted to the Royal Hospital for Sick Children under the care of Professor R. W. B. Ellis in August 1960 with the complaint that since February of that year he had been increasingly unable to walk. The patient was the result of a full-term spontaneous delivery after an uncomplicated pregnancy...

Familial cases with age-related macular degeneration.

BACKGROUND The pathogenesis of age-related macular degeneration (AMD) remains unknown. Genetic and environmental factors are thought to be associated with AMD. Although some studies have reported familial cases of AMD in the United States, as far as we know, familial cases of AMD have rarely been reported in Japan. CASES We describe three families with two members of each family affected with...

Macular Degeneration

the genetics of age-related macular degeneration

age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...

Macular pigment and age related macular degeneration.

The present concepts of the pathogenesis of AMD include cumulative light damage by oxidative processes in the macular photoreceptors as environmental co-factor for the development of AMD. The direct causative connection of this hypothesis has still to be established but wide circumstantial evidence from epidemiological and basic scientific investigations are strongly supportive. Macular pigment...